منابع مشابه
Characterizing functional domains for TIM-mediated enveloped virus entry.
UNLABELLED T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating virus on the cell surface, and promoting subsequent internalization. The PtdS...
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Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis, indicating that these viruses may also utilize alternate means for egress. Moreover, it appears that complex, non-enveloped viruses such as blueton...
متن کاملEntry and uncoating of enveloped viruses.
Markus LANZREIN,* Andreas SCHLEGELt and Christoph KEMPF1§11 *Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway, t University of Colorado at Boulder, Department of Molecular, Cellular and Developmental Biology, Campus Box 347, Boulder, CO 80309-0347, U.S.A., t Institute of Biochemistry, University of Bern, Freiestrasse 3, 3012...
متن کاملCell entry by non-enveloped viruses.
Interestingly, cell entry by non enveloped viruses that you really wait for now is coming. It's significant to wait for the representative and beneficial books to read. Every book that is provided in better way and utterance will be expected by many peoples. Even you are a good reader or not, feeling to read this book will always appear when you find it. But, when you feel hard to find it as yo...
متن کاملRole of the phosphatidylserine receptor TIM-1 in enveloped-virus entry.
The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the viral envelope. PtdSer liposomes but not phosphatidylcholine liposomes competed w...
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ژورنال
عنوان ژورنال: Cell
سال: 2020
ISSN: 0092-8674
DOI: 10.1016/j.cell.2020.06.033